Lymphoid cells that produce interleukin (IL)-17 cytokines protect barrier tissues from pathogenic
microbes but are also prominent effectors of inflammation and autoimmune disease. T …

Phosphoserine phosphatase (PSP) is a member of a large class of enzymes that catalyze
phosphoester hydrolysis using a phosphoaspartate–enzyme intermediate. PSP is a likely …

Unilateral vocal cord paralysis is a common finding in the practice of otolaryngology. Multiple
etiologies have been described and have not changed appreciably in the last century. We …

Background The burden of cirrhosis on the healthcare system is substantial and growing.
Our objectives were to estimate the readmission rates and hospitalization costs as well as to …

TGF-β signaling is fundamental for both Th17 and regulatory T (Treg) cell differentiation.
However, these cells differ in requirements for downstream signaling components, such as …

Background and aims Up to 20% of Primary Biliary Cholangitis (PBC) patients are
estimated to have features that overlap with Autoimmune Hepatitis (AIH). Patients with PBC-AIH …

Symptoms of fatigue, social withdrawal and mood disturbances are commonly encountered
in patients with chronic liver disease and have a detrimental effect on patient quality of life. …

d-glycero-d-manno-Heptose-1,7-bisphosphate phosphatase (GmhB) is a member of the
histidinol-phosphate phosphatase (HisB) subfamily of the haloalkanoic acid dehalogenase (…

Cardiac dysfunction associated with cirrhosis in the absence of preexisting heart disease is
a condition known as cirrhotic cardiomyopathy (CCM). Cardiac abnormalities consist of …

Given the incidence of corneal dysfunctions and diseases worldwide and the limited availability
of healthy, human donors, investigators are working to generate engineered cellular and …