Background Opioids are widely prescribed for chronic nonmalignant pain, often at doses
exceeding those recommended in clinical practice guidelines. However, the risk-benefit ratio of …

Importance Although wait times for hip fracture surgery have been linked to mortality and are
being used as quality-of-care indicators worldwide, controversy exists about the duration of …

Importance Opioid prescribing and overdose are leading public health problems in North
America, yet the precise public health burden has not been quantified. Objective To examine …

Background Prescription opioid use is highly associated with risk of opioid-related death,
with 1 of every 550 chronic opioid users dying within approximately 2.5 years of their first …

Background: Ankylosing spondylitis (AS) is a chronic inflammatory arthritis affecting the spine
in young adults. It is associated with excess cardiovascular and cerebrovascular morbidity. …

Objective To quantify an association between acute kidney injury and use of high potency
statins versus low potency statins. Design Retrospective observational analysis of …

Objectives To identify a cut point in annual surgeon volume associated with increased risk of
complications after primary elective total hip arthroplasty and to quantify any risk identified. …

Background: The aims of operative treatment of displaced tibial plateau fractures are to
stabilize the injured knee to restore optimal function and to minimize the risk of posttraumatic …

Background There is concern that antidiabetic incretin-based drugs, including dipeptidyl
peptidase 4 (DPP-4) inhibitors and glucagon-like peptide 1 (GLP-1) analogues, can increase …

Objective To evaluate the effectiveness of the community based Cardiovascular Health
Awareness Program (CHAP) on morbidity from cardiovascular disease. Design Community …