Somatic copy number amplification and gene overexpression are common features of many
cancers. To determine the role of gene overexpression on chromosome instability (CIN), we …

Background: Inappropriate prescribing increases patient illness and death owing to adverse
drug events. The inclusion of genetic information into primary care medication practices is …

Objective A simple, non-invasive sample collection method is key for the integration of
pharmacogenetics into clinical practice. The aim of this study was to gain samples for …

Mutations that cause genome instability are considered important predisposing events that
contribute to initiation and progression of cancer. Genome instability arises either due to …

The ability to rapidly assess chromosome instability (CIN) has enabled profiling of most
yeast genes for potential effects on genome stability. The A-like faker (ALF) assay is one of …

Cancer is due to an accumulation of mutations in constellations of genes that cause
uncontrolled proliferation and evasion of apoptotic pathways. In addition, mutations that cause …

Objective: A simple, non-invasive sample collection method is key for the integration of
pharmacogenetics into clinical practice. The aim of this study was to gain samples for …

Background: Despite free diagnosis and treatment for tuberculosis (TB), the costs during
treatment impose a significant financial burden on patients and their households. The study …

Somatic copy number amplifications (SCNAs) and gene over-expression are common features
of many cancers. To determine the role of gene over-expression on genome stability, we …

Genes. To discover genes that when overexpressed result in CIN, we screened an arrayed
collection of 5,100 yeast strains, each conditionally overexpressing a unique gene under the …