BACKGROUND Classification of endometrial carcinomas (ECs) by morphologic features is
irreproducible and imperfectly reflects tumor biology. The authors developed the Proactive …

OBJECTIVE: Prophylactic bilateral salpingo-oophorectomy is advised for women with BRCA
mutations, but there are adverse consequences of premature menopause. The majority of …

Background Retrospective data suggest that the incidence of parametrial infiltration is low in
patients with early-stage low-risk cervical cancer, which raises questions regarding the …

Importance Opportunistic salpingectomy (OS), which is the removal of fallopian tubes during
hysterectomy or instead of tubal ligation without removal of ovaries, is recommended to …

Purpose Women with endometrial cancer as a result of Lynch syndrome may not be identified
as such by Amsterdam II criteria. We estimated the costs and benefits of different testing …

PPP2R1A mutations have recently been described in 3/42 (7%) of clear cell carcinomas of
the ovary. PPP2R1A encodes the α‐isoform of the scaffolding subunit of the serine/threonine …

Purpose Every year approximately 25% of women diagnosed with breast cancer are younger
than 50 years of age, and almost 10% of them have a BRCA mutation. Not all potential …

OBJECTIVE: To conduct a cost-effectiveness analysis of opportunistic salpingectomy (elective
salpingectomy at hysterectomy or instead of tubal ligation). METHODS: A Markov Monte …

High-grade serous carcinoma (HGSC) is the most common and lethal subtype of ovarian
cancer. Research over the past decade has strongly suggested that “ovarian” HGSC arises in …

Women with Lynch syndrome (LS) are at increased risk for the development of epithelial
ovarian cancer (OC). Analogous to previous studies on BRCA1/2 mutation carriers, there is …