BACKGROUND: Although many Canadian studies have provided disease-specific or
patient group–specific utility scores, the utility score norms currently available for the general …

BACKGROUND: Recent trials report the efficacy of continuous tenofovir-based pre-exposure
prophylaxis (PrEP) for prevention of HIV infection. The cost effectiveness of ‘on demand’ …

Purpose High-dimensional propensity scores (hdPS) can adjust for measured confounders,
but it remains unclear how well it can adjust for unmeasured confounders. Our goal was to …

Background Comparative performance of the traditional propensity score (PS) and high-dimensional
propensity score (hdPS) methods in the adjustment for confounding by indication …

Background A sub-study of the Ontario Bariatric Registry was conducted to evaluate the
impact of bariatric surgery on mobility, health-related quality of life (HRQoL), healthcare …

Background While simple Audit & Feedback (A&F) has shown modest effectiveness in
reducing low-value care, there is a knowledge gap on the effectiveness of multifaceted …

Background and Objectives Nonvalvular atrial fibrillation (NVAF) is associated with an increased
risk of dementia. Oral anticoagulants (OACs) are essential for stroke prevention in NVAF…

Background Idiopathic pulmonary fibrosis (IPF), although rare, is a severe and costly disease.
Objective To estimate the clinical and economic burden of IPF over multiple years before …

… Jason R. Guertin is the recipient a of an establishment fund from the Centre de Recherche
du CHU de Québec – Université Laval and from the Fondation du CHU de Québec. …

Background Senior high cost health care users (HCU) are a priority for many governments.
Little research has addressed regional variation of HCU incidence and outcomes, especially …