Importance Severely injured patients experiencing hemorrhagic shock often require massive
transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red …

Background— Acute kidney injury (AKI) after cardiac surgery is a major health issue.
Lacking effective therapies, risk factor modification may offer a means of preventing this …

Cryoprecipitate is a diverse product containing factor VIII, von Willebrand factor, fibrinogen,
fibronectin, factor XIII, and platelet microparticles. The role of this complex product in the …

The author discusses American Association of Blood Banks (AABB) recommendations for
the Choosing Wisely campaign of the organization American Board of Internal Medicine (ABIM)…

BACKGROUND: Half of the reported serious adverse events from transfusion are a consequence
of medical error. A no‐fault medical‐event reporting system for transfusion medicine (…

The supernatant potassium concentration [K+] of red blood cell (RBC) units is frequently much
higher than normal human plasma potassium levels, especially in units nearing the end of …

Transfusion-associated circulatory overload (TACO) is an important and potentially injurious
complication of transfusion that is underappreciated by clinicians. Risk factors for TACO …

BACKGROUND: In cardiac surgery, excessive blood loss requiring large‐volume red blood
cell (RBC) transfusion is a common occurrence that is associated with significant morbidity …

BACKGROUND The Pragmatic, Randomized Optimal Platelets and Plasma Ratios (PROPPR)
trial was a randomized clinical trial comparing survival after transfusion of two different …

Background F rozen plasma ( FP ) is frequently transfused inappropriately, an intervention
that results in risk without benefit for the patient. To better understand current utilization …