The wound healing response is one of most primitive and conserved physiological responses
in the animal kingdom, as restoring tissue integrity/homeostasis can be the difference …

How distinct transcriptional programs are enacted to generate cellular heterogeneity and
plasticity, and enable complex fate decisions are important open questions. One key regulator …

Objective Pediatric burns are preventable with legislative and infrastructural changes. Although
retrospective audits of many low- and middle-income countries have aided preventative …

Proteoglycan 4 (PRG4) is a boundary lubricant originally identified in articular cartilage and
has been since shown to have immunomodulation and antifibrotic properties. Previously, we …

Background Randomized controlled clinical trials (CTs) are gold standard tools for assessing
interventions. Although burn CTs have improved care, their status, publication frequency, …

To maximize the effectiveness of rehabilitative therapies after stroke, it is critical to determine
when the brain is most responsive (ie, plastic) to sensorimotor experience after injury and to …

Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …

Chronic impairment of forelimb and digit movement is a common problem after stroke that is
resistant to therapy. Previous studies have demonstrated that enrichment improves …

A fundamental question in stem cell research is whether cultured multipotent adult stem cells
represent endogenous multipotent precursor cells. Here we address this question, focusing …

Although critical for host defense, innate immune cells are also pathologic drivers of acute
respiratory distress syndrome (ARDS). Innate immune dynamics during Coronavirus Disease …