Association of postoperative high-sensitivity troponin levels with myocardial injury and 30-day mortality among patients undergoing noncardiac surgery
Importance Little is known about the relationship between perioperative high-sensitivity
troponin T (hsTnT) measurements and 30-day mortality and myocardial injury after noncardiac …
troponin T (hsTnT) measurements and 30-day mortality and myocardial injury after noncardiac …
[HTML][HTML] Tranexamic acid in patients undergoing noncardiac surgery
Background Perioperative bleeding is common in patients undergoing noncardiac surgery.
Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding. Methods …
Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding. Methods …
Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial
Background Myocardial injury after non-cardiac surgery (MINS) increases the risk of
cardiovascular events and deaths, which anticoagulation therapy could prevent. Dabigatran …
cardiovascular events and deaths, which anticoagulation therapy could prevent. Dabigatran …
[HTML][HTML] Double-adjustment in propensity score matching analysis: choosing a threshold for considering residual imbalance
TL Nguyen, GS Collins, J Spence, JP Daurès… - BMC medical research …, 2017 - Springer
Background Double-adjustment can be used to remove confounding if imbalance exists after
propensity score (PS) matching. However, it is not always possible to include all covariates …
propensity score (PS) matching. However, it is not always possible to include all covariates …
Association between complications and death within 30 days after noncardiac surgery
J Spence, Y LeManach, MTV Chan, CY Wang… - Cmaj, 2019 - Can Med Assoc
BACKGROUND: Among adults undergoing contemporary noncardiac surgery, little is
known about the frequency and timing of death and the associations between perioperative …
known about the frequency and timing of death and the associations between perioperative …
Dexmedetomidine vs other sedatives in critically ill mechanically ventilated adults: a systematic review and meta-analysis of randomized trials
Conventional gabaminergic sedatives such as benzodiazepines and propofol are commonly
used in mechanically ventilated patients in the intensive care unit (ICU). Dexmedetomidine …
used in mechanically ventilated patients in the intensive care unit (ICU). Dexmedetomidine …
Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study
Background In non-surgical settings, covert stroke is more common than overt stroke and is
associated with cognitive decline. Although overt stroke occurs in less than 1% of adults after …
associated with cognitive decline. Although overt stroke occurs in less than 1% of adults after …
Hypotension-avoidance versus hypertension-avoidance strategies in noncardiac surgery: an international randomized controlled trial
…, D Stillo, A Kurz, EP Belley-Côté, J Spence… - Annals of internal …, 2023 - acpjournals.org
Background: Among patients having noncardiac surgery, perioperative hemodynamic
abnormalities are associated with vascular complications. Uncertainty remains about what …
abnormalities are associated with vascular complications. Uncertainty remains about what …
Tissue-specific BMAL1 cistromes reveal that rhythmic transcription is associated with rhythmic enhancer–enhancer interactions
…, CA Osborne, H Vitet, J Spence… - Genes & …, 2019 - genesdev.cshlp.org
The mammalian circadian clock relies on the transcription factor CLOCK: BMAL1 to coordinate
the rhythmic expression of thousands of genes. Consistent with the various biological …
the rhythmic expression of thousands of genes. Consistent with the various biological …
[HTML][HTML] High-sensitivity troponin I after cardiac surgery and 30-day mortality
…, MJ McQueen, K Brady, J Spence… - New England journal …, 2022 - Mass Medical Soc
Background Consensus recommendations regarding the threshold levels of cardiac troponin
elevations for the definition of perioperative myocardial infarction and clinically important …
elevations for the definition of perioperative myocardial infarction and clinically important …