Global cancer prevalence has continuously increased in the last decades despite substantial
progress achieved for patient care. Cancer is no longer recognized as a singular disease …

Due mainly to their poor stability and short plasma half-life, peptides are usually administered
by injection, often several times daily. Injectable sustained-release formulations of …

Therapeutic peptides have become very successful drugs due to their specificity, potency and
low toxicity, but they show challenges for their delivery, due to their short half-life and rapid …

Pseudomonas fluorescens and related plant root (“rhizosphere”)-associated species
contribute to plant health by modulating defenses and facilitating nutrient uptake. To identify …

As a molecular model of gelatin-free coacervates, complexes of pea globulin and α gliadin
proteins with gum arabic prepared at different acidic pH values are studied using Raman …

The aim of this work was to assess the influence of various formulation parameters on the
incorporation of a poorly water-soluble crystalline drug into nanoparticles. For this purpose, the …

The busulfan is an alkylating agent widely used for the treatment of haematological malignancies
and nonmalignant disorders. For a long time, it has been available only in an oral form. …

This article presents BEPO®, an in situ forming depot (ISFD) technology mediated by a
solvent-exchange mechanism. The matrix of the in situ formed drug delivery depot is composed …

The generation of acylated impurities has represented an important hurdle in the development
of long acting injectables for therapeutic peptides using biocompatible polymers with a …

Introduction The development of long-acting injectables (LAIs) for protein and peptide
therapeutics has been a key challenge over the last 20 years. If these molecules offer advantages …