Cytochrome P450 3A: ontogeny and drug disposition
The maturation of organ systems during fetal life and childhood exerts a profound effect on
drug disposition. The maturation of drug-metabolising enzymes is probably the predominant …
drug disposition. The maturation of drug-metabolising enzymes is probably the predominant …
Guidelines on paediatric dosing on the basis of developmental physiology and pharmacokinetic considerations
…, AFAM Schobben, JN Van Den Anker - Clinical …, 2006 - Springer
The approach to paediatric drug dosing needs to be based on the physiological characteristics
of the child and the pharmacokinetic parameters of the drug. This review summarises the …
of the child and the pharmacokinetic parameters of the drug. This review summarises the …
Glucuronidation in humans: pharmacogenetic and developmental aspects
During human development impressive changes in drug disposition occur. An important
determinant of drug clearance is metabolism, something that is not only determined by …
determinant of drug clearance is metabolism, something that is not only determined by …
Survey of unlicensed and off label drug use in paediatric wards in European countries
…, F Rocchi, M Bonati, M de Hoog, J van den Anker - bmj, 2000 - bmj.com
Objective: To determine the extent of use of unlicensed and off label drugs in children in
hospital in five European countries. Design: Prospective study of drugs administered to children …
hospital in five European countries. Design: Prospective study of drugs administered to children …
Neonatal drug withdrawal
Maternal use of certain drugs during pregnancy can result in transient neonatal signs consistent
with withdrawal or acute toxicity or cause sustained signs consistent with a lasting drug …
with withdrawal or acute toxicity or cause sustained signs consistent with a lasting drug …
The transfer of drugs and therapeutics into human breast milk: an update on selected topics
…, T Johnson, K Neville, IM Paul, J Van den Anker - …, 2013 - publications.aap.org
Many mothers are inappropriately advised to discontinue breastfeeding or avoid taking essential
medications because of fears of adverse effects on their infants. This cautious approach …
medications because of fears of adverse effects on their infants. This cautious approach …
CYP3A5 Variant Allele Frequencies in Dutch Caucasians
…, IP van der Heiden, JN van den Anker… - Clinical …, 2002 - academic.oup.com
Background: Enzymes of the cytochrome P450 3A (CYP3A) family are responsible for the
metabolism of >50% of currently prescribed drugs. CYP3A5 is expressed in a limited number …
metabolism of >50% of currently prescribed drugs. CYP3A5 is expressed in a limited number …
More codeine fatalities after tonsillectomy in North American children
In 2009 we reported the fatal case of a toddler who had received codeine after adenotonsillectomy
for obstructive sleep apnea syndrome. The child was an ultra-rapid metabolizer of …
for obstructive sleep apnea syndrome. The child was an ultra-rapid metabolizer of …
Impact of obesity on drug metabolism and elimination in adults and children
…, S Van Kralingen, JN van den Anker… - Clinical …, 2012 - Springer
The prevalence of obesity in adults and children is rapidly increasing across the world.
Several general (patho)physiological alterations associated with obesity have been described, …
Several general (patho)physiological alterations associated with obesity have been described, …
Off-label use of drugs in children
The passage of the Best Pharmaceuticals for Children Act and the Pediatric Research
Equity Act has collectively resulted in an improvement in rational prescribing for children, …
Equity Act has collectively resulted in an improvement in rational prescribing for children, …
