Background Budget impact analyses (BIAs) are an essential part of a comprehensive
economic assessment of a health care intervention and are increasingly required by …

Context National public insurance for drugs is often based on evidence of comparative
effectiveness and cost-effectiveness. This study describes how that evidence has been used …

Mineral sands mining involves stripping topsoil to access heavy-mineral bearing deposits,
which are then rehabilitated to their original state, commonly pasture in south-west Western …

The structural maintenance of chromosome (SMC) proteins are key elements in controlling
chromosome dynamics. In eukaryotic cells, three essential SMC complexes have been …

Cyclin-dependent kinases (Cdks) are fully active only when phosphorylated by a Cdk-activating
kinase (CAK) [1]. Metazoan CAK is itself a Cdk, Cdk7, whereas the CAK of …

The fission yeast Mcs6–Mcs2–Pmh1 complex, homologous to metazoan Cdk7–cyclin H-Mat1,
has dual functions in cell division and transcription: as a partially redundant cyclin-…

Objective: To assess the cost effectiveness of nasal calcitonin (Miacalcin®) compared with
no therapy, alendronate or etidronate in the treatment of postmenopausal women with …

Perrault syndrome is a genetically heterogeneous recessive disorder characterized by
ovarian dysgenesis and sensorineural hearing loss. In a nonconsanguineous family with five …

Perrault syndrome is a recessive disorder characterized by ovarian dysgenesis in females,
sensorineural deafness in both males and females, and in some patients, neurological …

Economic models are used to assess health care technologies (for example, drugs, medical
devices, and diagnostics) to understand potential clinical effects and costs (ie, those …