Importance Surgical site infection (SSI) complicates 2-5% of surgeries in the United States.
Severity of SSI ranges from superficial skin infection to life-threatening conditions such as …

Background Major depressive disorder (MDD) is a global public health concern. In particular,
treatment-resistant depression (TRD) represents a key unmet need in the management of …

Background Preterm birth is a major risk factor for morbidity and mortality among infants
worldwide, and imposes considerable burden on health, education and social services, as well …

Objectives To provide a national estimate of the incidence of hospitalizations due to osteoporotic
fractures (OFs) in women; compare this with the incidence of myocardial infarction (MI), …

We developed a mathematical model using a multiple source of infection framework to
assess the potential effect of the expansion of highly active antiretroviral therapy (HAART) …

Objective To estimate the association between the use of sodium glucose co-transporter-2 (SGLT2)
inhibitors and postmarket harms as identified by drug regulatory agencies. Design …

Background Expert national/global asthma management recommendations raise the issue
whether a safe threshold of short-acting beta-2 agonist (SABA) use without concomitant …

Background/objectives: Available metrics for characterizing cumulative anticholinergic
exposure over time may not be well suited for use across all US data sources. In this review, the …

Background: More than half of all heart disease and stroke are attributable to hypertension,
which is associated with approximately 10% of direct medical costs globally. Clinical trial …

Background Observational burden of illness studies are used in pharmacoepidemiology to
address a variety of objectives, including contextualizing the current treatment setting, …