User profiles for Keith C.K. Lau
 | Keith CK LauUniversity of Calgary Verified email at ucalgary.ca Cited by 375 |
[HTML][HTML] Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma
Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead
to cirrhosis, cancer, and liver failure. Liver cancer is the third leading cause of cancer-…
to cirrhosis, cancer, and liver failure. Liver cancer is the third leading cause of cancer-…
[HTML][HTML] Impact of hepatitis B virus genetic variation, integration, and lymphotropism in antiviral treatment and oncogenesis
Chronic Hepatitis B Virus (HBV) infection poses a significant global health burden. Although,
effective treatment and vaccinations against HBV are available, challenges still exist, …
effective treatment and vaccinations against HBV are available, challenges still exist, …
[HTML][HTML] Identification and characterization of a G-quadruplex structure in the pre-core promoter region of hepatitis B virus covalently closed circular DNA
Approximately 250 million people worldwide are chronically infected with the hepatitis B virus
(HBV) and are at increased risk of developing cirrhosis and hepatocellular carcinoma. The …
(HBV) and are at increased risk of developing cirrhosis and hepatocellular carcinoma. The …
Oncogenic HBV variants and integration are present in hepatic and lymphoid cells derived from chronic HBV patients
The hepatitis B virus (HBV) is a major cause of hepatocellular carcinoma (HCC), partly
driven by viral integration and specific oncogenic HBV variants. However, the biological …
driven by viral integration and specific oncogenic HBV variants. However, the biological …
[HTML][HTML] Differences in HBV replication, APOBEC3 family expression, and inflammatory cytokine levels between wild-type HBV and pre-core (G1896A) or basal core …
Background Chronic hepatitis B virus (HBV) infection is the leading cause of hepatocellular
carcinoma (HCC) world-wide. HBV variants, particularly the G1896A pre-core (PC) and …
carcinoma (HCC) world-wide. HBV variants, particularly the G1896A pre-core (PC) and …
Hepatitis B virus (HBV) genome detection and genotyping in virally suppressed patients using nested polymerase chain reaction-based Sanger sequencing
Hepatitis B virus (HBV) genotypes have important clinical implications. Current genotyping
methods are less sensitive in patients with ultra-low HBV viral load. We report a highly …
methods are less sensitive in patients with ultra-low HBV viral load. We report a highly …
Analysis of serum hepatitis B virus RNA levels in a multiethnic cohort of pregnant chronic hepatitis B carriers
Background Hepatitis B virus (HBV) flares have been reported due to alterations in the
immune system during pregnancy. Recent studies in non-pregnant chronic hepatitis B (CHB) …
immune system during pregnancy. Recent studies in non-pregnant chronic hepatitis B (CHB) …
Hepatitis B virus testing and linkage to care in a Canadian urban tertiary referral centre: a retrospective cohort study
KCK Lau, AA Shaheen, AA Aspinall… - … Open Access Journal, 2017 - cmajopen.ca
Background: Despite universal vaccination, chronic hepatitis B virus (HBV) infection remains
a public health concern in North America owing to immigration. We aimed to characterize …
a public health concern in North America owing to immigration. We aimed to characterize …
Immune-based therapy for hospitalized patients with COVID-19 and risk of secondary infections: A systematic review and meta-analysis
Background Immune-based therapies are standard-of-care treatment for coronavirus disease
2019 (COVID-19) patients requiring hospitalization. However, safety concerns related to …
2019 (COVID-19) patients requiring hospitalization. However, safety concerns related to …
An affront to scientific inquiry re: Moore, DR (2018) editorial: Auditory processing disorder, Ear Hear, 39, 617–620
…, H Thai-Van, A Kostopoulou, E Veuillet, B Keith… - Ear and …, 2018 - journals.lww.com
LETTERS TO THE EDITOR 1237 not as a result of methodological design flaws, but rather
because the reviewers considered the disorder controversial and difficult to verify. This …
because the reviewers considered the disorder controversial and difficult to verify. This …