Background: Direct-to-consumer advertising (DTCA) of prescription drugs has increased
rapidly in the United States during the last decade, yet little is known about its effects on …

Only the United States and New Zealand allow advertising of prescription drugs directed at
patients. US spending on such advertising grew rapidly during the 1990s, reaching $2.47 bn (…

BACKGROUND: Many individual surveys of blindness have reported slightly higher rates of
blindness for women. In order to gain a continent-by-continent and global sense of the …

Background Elevated blood pressure (known as hypertension) increases with age, and most
rapidly over age 60. Systolic hypertension is more strongly associated with cardiovascular …

Background Hypertension is a modifiable cardiovascular risk factor. Although it is established
that low‐dose thiazides reduce mortality as well as cardiovascular morbidity, the dose‐…

Background Clinical trials and meta-analyses have found that rosiglitazone maleate, a
thiazolidinedione that is prescribed for type 2 diabetes mellitus, increases the risk of fractures in …

Background Chronic heart failure (HF) is a prevalent world‐wide. Angiotensin receptor
blockers (ARBs) are widely prescribed for chronic HF although their role is controversial. …

Background Presbyopia, age-related decline in near vision, is the most common cause of
vision impairment globally, but no trials have assessed its workplace effects. We aimed to …

To the Editor: The authors of the CLASS trial1 reported that celecoxib caused fewer symptomatic
ulcers and ulcer complications than did diclofenac or ibuprofen at 6 months of followup. …

This paper deals with certain basic extensions to the general conceptual~ ramework of a
multiregion social system. These extensions relate to the inclusion of the ecologic system into …