Human interferon‐inducible protein 10 (IP‐10) differs from most chemokines in its apparent
specificity for activated T lymphocytes. We hypothesized that IP‐10 was relevant not only for …

Rationale: Evidence is emerging that exposure to maternal distress in early life plays a causal
role in the development of childhood asthma. Objectives: Because much of the data are …

The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study recruited
3624 pregnant women, most partners and 3542 eligible offspring. We hypothesise that …

Cytokine patterns elicited by infection are critical in the regulation of the adaptive immune
response and in the resolution of infection. Using a murine model of pneumonia induced by …

BACKGROUND: In animal models administration of immunostimulatory DNA sequences
preferentially elicits T H 1-dominated (type 1-dominated) immunity and can inhibit developing …

The interaction between chemokines and their receptors is an important step in the control of
leukocyte migration into sites of inflammation. Chemokines also mediate a variety of effects …

Dietary phytosterols significantly reduce atherosclerosis in apo E-deficient mice. Because
atherosclerosis is a chronic inflammatory disease, we investigated whether the …

Phosphoinositide 3‐kinases (PI3K) regulate immune activation via their roles in signal
transduction of multiple classes of receptors. Here, we examined the effect of genetic inactivation …

The sensitivity of [ 3 H]thymidine incorporation and MTT/MTS colorimetric bioassays for
detection and quantitation of murine and human IL-4 and IL-2 were compared in CT.4S, CT.h4S …

We tested peptide immunotherapy in cat-allergic humans, using a formulation of two synthetic
peptides, IPC-1 and IPC-2, each of which is 27 amino acids long and contains T cell-…