Background A significant barrier to conducting clinical trials is their high cost, which is driven
primarily by the time and resources required to activate trials and reach accrual targets. The …

Background: An important challenge with the application of next-generation sequencing
technology is the possibility of uncovering incidental genomic findings. A paucity of evidence on …

Context Symptom clusters in advanced cancer can influence patient outcomes. There is large
heterogeneity in the methods used to identify symptom clusters. Objectives To investigate …

Objective To evaluate the validity of cancer-specific and generic preference-based instruments
to discriminate across different measures of cancer severities. Methods Patients with …

We investigated if long-term resistance training would increase insulin-like growth factor-1 (IGF-1)
bioavailabilty at rest in older women (68±1 years) with low bone mineral density. IGF-1 …

Objective To help facilitate economic evaluations of oncology treatments, we mapped responses
on cancer-specific instrument to generic preference-based measures. Methods Cancer …

… Kimberly van der Hoek and Nadine Caron contributed to acquisition and interpretation of
the data. All authors revised the manuscript critically for important intellectual content. All …

Introduction: Erlotinib was recently approved in British Columbia (BC) as a second-line
treatment for advanced NSCLC. A cost-effectiveness analysis was conducted which compares …

Erlotinib has been approved as a third-line treatment for advanced non-small-cell lung
cancer (NSCLC) in British Columbia (BC). A cost-effectiveness analysis was conducted to …

It was examined whether physical activity could alter the bioavailability of insulin-like growth
factor-1 (IGF-1) which is dependent upon plasma IGF-1 and insulin-like growth factor …