Deep brain stimulation (DBS) is an established therapeutic modality for the treatment of
movement disorders and an emerging therapeutic approach for the treatment of disorders of …

The water maze is commonly used to assay spatial cognition, or, more generally, learning
and memory in experimental rodent models. In the water maze, mice or rats are trained to …

In the hippocampus, the production of dentate granule cells (DGCs) persists into adulthood.
As adult‐generated neurons are thought to contribute to hippocampal memory processing, …

Heterozygous loss-of-function mutations in SHANK2 are associated with autism spectrum
disorder (ASD). We generated cortical neurons from induced pluripotent stem cells derived …

Autism spectrum disorder (ASD) is phenotypically and genetically heterogeneous. We present
a CRISPR gene editing strategy to insert a protein tag and premature termination sites …

Background The Xp22.11 locus that encompasses PTCHD1, DDX53, and the long noncoding
RNA PTCHD1-AS is frequently disrupted in male subjects with autism spectrum disorder (…

Autism spectrum disorder (ASD) is an early-onset neurodevelopmental disorder characterized
by deficits in social communication, and restricted and repetitive patterns of behavior. …

A progressive increase in MECP2 protein levels is a crucial and precisely regulated event
during neurodevelopment, but the underlying mechanism is unclear. We report that MECP2 is …

Regulation of translation during human development is poorly understood, and its
dysregulation is associated with Rett syndrome (RTT). To discover shifts in mRNA ribosomal …

Background Williams-Beuren Syndrome (WBS) is caused by the microdeletion of approximately
25 genes on chromosome 7q11.23, and is characterized by a spectrum of cognitive and …