We have discovered that all known yeast and vertebrate small nucleolar RNAs (snoRNAs),
except for the MRP/7–2 RNA, fall into two major classes. One class is defined by conserved …

Dominant mutations of the Knotted-1 (Kn1) homeobox gene of maize alter the differentiation
and growth of cells associated with leaf veins. By analyzing Kn1 transcripts and KN1 protein…

Neurodevelopmental disorders (NDDs) affect more than 3% of children and are attributable
to single-gene mutations at more than 1000 loci. Traditional methods yield molecular …

Previous work has shown that the 0.02-0.05% of adult mouse bone marrow cells that bear
the cell surface phenotype Thy-1loLin-Sca-1+ are enriched 1000- to 2000-fold for …

Coexpression networks and gene regulatory networks (GRNs) are emerging as important
tools for predicting functional roles of individual genes at a system-wide scale. To enable …

Background Genetic disorders and congenital anomalies are the leading causes of infant
mortality. Diagnosis of most genetic diseases in neonatal and paediatric intensive care units (…

The product of the maize homeobox gene, knotted1 (kn1), localizes to the nuclei of cells in
shoot meristems, but is absent from portions of the meristem where leaf primordia or floral …

While the cost of whole genome sequencing (WGS) is approaching the realm of routine
medical tests, it remains too tardy to help guide the management of many acute medical …

The cytoskeleton plays important roles in plant cell shape determination by influencing the
patterns in which cell wall materials are deposited. Cortical microtubules are thought to orient …

Wingless, the Drosophila homologue of the proto-oncogene Wnt-1, encodes a secreted
glycoprotein that regulates differentiation and proliferation of nearby cells. Here we report on the …