New diagnostic criteria for multiple sclerosis integrating magnetic resonance image
assessment with clinical and other paraclinical methods were introduced in 2001. The “McDonald …

The capacity of minocycline to alleviate disease for several neurological disorders in animals
is increasingly being recognised. Indeed, that one drug alone can attenuate the severity of …

Multiple sclerosis is characterized by the infiltration of leukocytes into the CNS. As matrix
metalloproteinases (MMPs) facilitate the passage of leukocytes across matrix barriers, we …

Background: The prevalence of major depression (MD) in persons with nonpsychiatric medical
conditions is an indicator of clinical need in those groups, an indicator of the feasibility of …

Objective: To describe the regional distribution of multiple sclerosis (MS) prevalence in
Canada, controlling for age and sex. Methods: This study used data from the Canadian …

Background On the basis of encouraging preliminary results, we conducted a randomized,
controlled trial to determine whether minocycline reduces the risk of conversion from a first …

The objective of this paper was to evaluate the lifetime and point prevalence of major
depression in a population-based Multiple Sclerosis (MS) clinic sample, and to describe …

The matrix metalloproteinases (MMPs) are implicated in the pathology of multiple sclerosis (MS).
This review summarizes the consequences of upregulation of MMP members in MS as …

We report a trial of minocycline in people with relapsingremitting multiple sclerosis (RRMS)
that evaluates safety and estimates its effect on magnetic resonance imaging (MRI). Ten …

Epigenetic changes influence gene expression without altering the DNA sequence. DNA
methylation, histone modification and microRNA-associated post-transcriptional gene silencing …