Most COVID-19 vaccines are designed to elicit immune responses, ideally neutralizing
antibodies (NAbs), against the SARS-CoV-2 spike protein. Several vaccines, including mRNA, …

The mammalian intestinal tract harbors a diverse community of trillions of microorganisms,
which have co-evolved with the host immune system for millions of years. Many of these …

Background: Risk factors for severe outcomes of SARS-CoV-2 infection are not well established
in children. We sought to describe pediatric hospital admissions associated with SARS-…

Maternal immunisation has the potential to substantially reduce morbidity and mortality from
infectious diseases after birth. The success of tetanus, influenza, and pertussis immunisation …

The risk and severity of specific infections are increased during pregnancy due to a
combination of physiological and immunological changes. Characterizing the maternal immune …

Importance There are limited high-quality, population-level data about the effect of SARS-CoV-2
infection on pregnancy using contemporaneous comparator cohorts. Objectives To …

Background The Canadian COVID-19 immunization strategy deferred second doses and
allowed mixed schedules. We compared two-dose vaccine effectiveness (VE) by vaccine type (…

Neonates, especially those born prematurely, are at high risk of morbidity and mortality from
sepsis. Multiple factors, including prematurity, invasive life-saving medical interventions, and …

Background Vaccinating children (≤17 years old) is important for controlling the COVID-19
pandemic. As parents are primary decision makers for their children, we aimed to assess …

Background A correlate of protection (CoP) is an immunological marker associated with
protection against infection. Despite an urgent need, a CoP for SARS-CoV-2 is currently …