Background Intravenous thrombolysis with alteplase bolus followed by infusion is a global
standard of care for patients with acute ischaemic stroke. We aimed to determine whether …

Background Nerinetide, an eicosapeptide that interferes with post-synaptic density protein
95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia-reperfusion. …

Background and Purpose— Minor stroke and transient ischemic attack with an intracranial
occlusion are associated with neurological deterioration and disability. Tenecteplase (TNK–…

Importance Early treatment of patients with transient ischemic attack (TIA) reduces the risk of
stroke. However, many patients present with symptoms that have an uncertain diagnosis. …

Background Individuals with minor ischaemic stroke and intracranial occlusion are at
increased risk of poor outcomes. Intravenous thrombolysis with tenecteplase might improve …

Objective To validate the previously derived Canadian TIA Score to stratify subsequent
stroke risk in a new cohort of emergency department patients with transient ischaemic attack. …

Importance Optimal blood pressure (BP) targets for the prevention of cognitive impairment
remain uncertain. Objective To explore the association of intensive (ie, lower than usual) BP …

Importance Atrial cardiopathy is associated with stroke in the absence of clinically apparent
atrial fibrillation. It is unknown whether anticoagulation, which has proven benefit in atrial …

Background The use of thrombolysis in acute stroke is an important indicator of the quality
of stroke care, because it requires health care providers to work collaboratively, rapidly and …

Objective To describe sex differences in the presentation, diagnosis, and revision of diagnosis
after early brain MRI in patients who present with acute transient or minor neurologic …