In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that
LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass …

Background Patients admitted to intensive-care units are at high risk of health-care-associated
infections, and many are caused by antimicrobial-resistant pathogens. We aimed to …

Cardiovascular disease (CVD) is the leading cause of mortality in women. In fact, CVD is
responsible for a third of all deaths of women worldwide and half of all deaths of women over …

Sputum smear examination for acid-fast bacilli (AFB) can diagnose up to 50–60% of cases
of pulmonary tuberculosis in well-equipped laboratories. In low-income countries, poor …

The importance of reinfection as a cause for recurrence of tuberculosis is unclear and has
potential public-health implications. We systematically searched published material for studies …

Background— Although obesity is associated with important hemodynamic disturbances,
there are few data on population-wide blood pressure (BP) distribution in children and …

Purpose : Incontinence affects between 3% and 60% of patients after radical prostatectomy.
Insertion of an artificial urinary sphincter is a mainstay therapeutic option available to these …

Hereditary tyrosinemia results from an inborn error in the final step of tyrosine metabolism.
The disease is known to cause acute and chronic liver failure, renal Fanconi's syndrome, and …

Background Hepatocellular carcinoma (HCC) is characterized by late detection and fast
progression, and it is believed that epigenetic disruption may be the cause of its molecular and …

Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protein convertase
that posttranslationally promotes the degradation of the low-density lipoprotein receptor (…