User profiles for Mark C. Walker

Mark C. Walker

Chair of the Department of Obstetrics and Gyneocology
Verified email at ohri.ca
Cited by 43063

Changes in homocysteine levels during normal pregnancy

MC Walker, GN Smith, SL Perkins, EJ Keely… - American journal of …, 1999 - Elsevier
Objective: The objective of this study was to determine the changes in total plasma
homocysteine concentration that occur during normal pregnancy. Study Design: In this cross-…

Kinetic basis for selective inhibition of cyclo-oxygenases

JK Gierse, CM Koboldt, MC Walker, K Seibert… - Biochemical …, 1999 - portlandpress.com
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the formation of prostaglandins by
cyclo-oxygenases (COX). The discovery of a second COX isoform (COX-2) associated with …

Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB

MA Ortega, Y Hao, Q Zhang, MC Walker… - Nature, 2015 - nature.com
Lantibiotics are a class of peptide antibiotics that contain one or more thioether bonds. The
lantibiotic nisin is an antimicrobial peptide that is widely used as a food preservative to …

Folic acid supplementation in early second trimester and the risk of preeclampsia

…, GN Smith, RJ Sigal, SL Perkins, MC Walker - American journal of …, 2008 - Elsevier
OBJECTIVE: The objective of the study was to evaluate the association between folic acid
supplementation in early second trimester and the risk of developing preeclampsia. STUDY …

A history of preeclampsia identifies women who have underlying cardiovascular risk factors

GN Smith, MC Walker, A Liu, SW Wen… - American journal of …, 2009 - Elsevier
OBJECTIVE: The objective of this study was to prospectively assess physical and biochemical
cardiovascular risk markers in women who had developed preeclampsia (PE) at 1 year …

[HTML][HTML] Comparison of risk factors and outcomes of gestational hypertension and pre-eclampsia

M Shen, GN Smith, M Rodger, RR White, MC Walker… - PloS one, 2017 - journals.plos.org
Background It remains an enigma whether gestational hypertension (GH) and pre-eclampsia
(PE) are distinct entities or different spectrum of the same disease. We aimed to compare …

Association of COVID-19 vaccination in pregnancy with adverse peripartum outcomes

…, CA Gravel, K Wilson, D El-Chaâr, MC Walker… - Jama, 2022 - jamanetwork.com
Importance There is limited comparative epidemiological evidence on outcomes associated
with COVID-19 vaccination during pregnancy; monitoring pregnancy outcomes in large …

Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways

MC Walker, BW Thuronyi, LK Charkoudian, B Lowry… - Science, 2013 - science.org
Organofluorines represent a rapidly expanding proportion of molecules that are used in
pharmaceuticals, diagnostics, agrochemicals, and materials. Despite the prevalence of fluorine …

Adverse maternal outcomes in multifetal pregnancies

MC Walker, KE Murphy, S Pan, Q Yang… - … Journal of Obstetrics …, 2004 - Wiley Online Library
In this retrospective cohort of 165,188 singleton pregnancies and 44,674 multiple‐fetal
pregnancies in Canada from 1984 to 2000, we compared the incidence of maternal complications…

H1N1 influenza vaccination during pregnancy and fetal and neonatal outcomes

…, SW Wen, G Smith, MC Walker… - … journal of public …, 2012 - ajph.aphapublications.org
Objectives. We evaluated the relationship between maternal H1N1 vaccination and fetal
and neonatal outcomes among singleton births during the 2009–2010 H1N1 pandemic. …