Immune thrombocytopenia (ITP) is commonly encountered in clinical practice. In 1996 the
American Society of Hematology published a landmark guidance paper designed to assist …

This article concerning the pharmacokinetics and pharmacodynamics of vitamin K antagonists
(VKAs) is part of the American College of Chest Physicians Evidence-Based Clinical …

Background This article addresses the treatment of VTE disease. Methods We generated
strong (Grade 1) and weak (Grade 2) recommendations based on high-quality (Grade A), …

Background The objective of this article is to summarize the published literature concerning
the pharmacokinetics and pharmacodynamics of oral anticoagulant drugs that are currently …

Executive Summary Antithrombotic Therapy and Prevention of Thrombosis, 9th ed:
American College of Chest Physicians Evidence-Based Clinical Practice Guidelines

Background High-quality anticoagulation management is required to keep these narrow
therapeutic index medications as effective and safe as possible. This article focuses on the …

Background Warfarin is a highly efficacious oral anticoagulant, but its use is limited by a well-founded
fear of bleeding. Drug and food interactions are frequently cited as causes of …

Background Bleeding is a complication of treatment with factor Xa inhibitors, but there are
no specific agents for the reversal of the effects of these drugs. Andexanet is designed to …

Background Many patients with the antiphospholipid antibody syndrome and recurrent
thrombosis receive doses of warfarin adjusted to achieve an international normalized ratio (INR) …

Background Heparin-induced thrombocytopenia (HIT) is an antibody-mediated adverse drug
reaction that can lead to devastating thromboembolic complications, including pulmonary …