Background Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease
worldwide and the leading cause of liver-related morbidity and mortality. We aimed to predict …

In inflammatory diseases occurring outside the CNS, communication between the periphery
and the brain via humoral and/or neural routes results in central neural changes and …

Fatigue is an extremely common complaint among patients with chronic disease. However,
because of the subjective nature of fatigue, and the lack of effective therapeutics with which …

BACKGROUND & AIMS:: A sustained virologic response (SVR) to therapy for hepatitis C virus
(HCV) infection is defined as the inability to detect HCV RNA 24 weeks after completion of …

Background Primary biliary cholangitis is a rare, chronic cholestatic liver disease characterized
by the destruction of interlobular bile ducts, leading to cholestasis and liver fibrosis. …

Background & Aims Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent, yet largely
underappreciated liver condition which is closely associated with obesity and metabolic …

Objective: To determine whether endogenous opioids contribute to the pruritus of cholestasis
by studying the effect of the opiate antagonist naloxone on the perception of pruritus and …

Interferon–α therapy is of proven efficacy in chronic hepatitis C, but it is not universally effective
and may be associated with intolerable side effects. Ribavirin is a nucleoside analog with …

BACKGROUND & AIMS: Overproduction of nitric oxide by inducible nitric oxide synthase (iNOS)
has been proposed as a pathogenic factor in colitis. The objective of this study was to …

A growing body of evidence now highlights a key role for inflammation in mediating sickness
behaviors and depression. Systemic inflammatory diseases such as rheumatoid arthritis, …