Megakaryocytes (MKs) are bone marrow–derived cells that are primarily responsible for
generating platelets for the maintenance of hemostasis. Although MK can variably express …

Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related
fatalities and is characterized by acute respiratory distress following blood transfusion. Donor …

Transfusion-related acute lung injury (TRALI) is a hazardous transfusion complication with an
associated mortality of 5% to 15%. We previously showed that stored (5 days) but not fresh …

Extracellular vesicles (EVs) derived from amniotic fluid stem cells (AFSCs) mediate anti-apoptotic,
pro-angiogenic, and immune-modulatory effects in multiple disease models, such as …

Both physiological homeostasis and pathological disease processes in the lung typically
result from complex, yet coordinated multicellular responses that are synchronized via …

Improvements in identification and assessment of extracellular vesicles (EVs) have fuelled a
recent surge in EV publications investigating their roles as biomarkers and mediators of …

Objectives: Transfusion-related acute lung injury is characterized by the onset of respiratory
distress and acute lung injury following blood transfusion, but its pathogenesis remains …

Inflammasomes are multiprotein complexes tasked with sensing endogenous or exogenous
inflammatory signals and integrating this signal into a downstream response. Inflammasome …

Transfusion-related acute lung injury (TRALI) is a syndrome of respiratory distress upon
blood transfusion and is the leading cause of transfusion-related fatalities. Whether the gut …

Background: A massive hemorrhage protocol (MHP) enables rapid delivery of blood components
in a patient who is exsanguinating pending definitive hemorrhage control, but there is …