Gut bacteria modulate the response to immune checkpoint blockade (ICB) treatment in cancer,
but the effect of diet and supplements on this interaction is not well studied. We assessed …

The development of the microbiome from infancy to childhood is dependent on a range of
factors, with microbial–immune crosstalk during this time thought to be involved in the …

Background Almost a third of patients with epilepsy have a treatment-resistant form, which is
associated with severe morbidity and increased mortality. Cannabis-based treatments for …

Abstract Treatment with combined immune checkpoint blockade (CICB) targeting CTLA-4 and
PD-1 is associated with clinical benefit across tumor types, but also a high rate of immune-…

The Encyclopedia of DNA Elements (ENCODE), http://encodeproject.org , has completed its
fifth year of scientific collaboration to create a comprehensive catalog of functional elements …

The University of California Santa Cruz (UCSC) Genome Browser ( http://genome.ucsc.edu )
offers online public access to a growing database of genomic sequence and annotations for …

Background Most studies describing the human gut microbiome in healthy and diseased states
have emphasized the bacterial component, but the fungal microbiome (ie, the mycobiome…

Objective: HIV dementia is an important neurological complication of advanced HIV infection.
The use of a cross-cultural screening test to detect HIV dementia within the international …

Background Bone is the most common site of metastatic disease associated with breast cancer
(BC). Bisphosphonates inhibit osteoclast‐mediated bone resorption, and novel targeted …

Objective To evaluate the safety and preliminary pharmacokinetics of a pharmaceutical
formulation of purified cannabidiol (CBD) in children with Dravet syndrome. Methods Patients …