Novel antibiotics are urgently needed to address the looming global crisis of antibiotic
resistance. Historically, the primary source of clinically used antibiotics has been microbial …

Differential expression analysis in single-cell transcriptomics enables the dissection of cell-type-specific
responses to perturbations such as disease, trauma, or experimental …

Microbial natural products are an invaluable source of evolved bioactive small molecules
and pharmaceutical agents. Next-generation and metagenomic sequencing indicates …

Microbial natural products represent a rich resource of pharmaceutically and industrially
important compounds. Genome sequencing has revealed that the majority of natural products …

A spinal cord injury interrupts pathways from the brain and brainstem that project to the
lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural electrical …

Microbial natural products are an evolved resource of bioactive small molecules, which form
the foundation of many modern therapeutic regimes. Ribosomally synthesized and …

Polyketides (PKs) and nonribosomal peptides (NRPs) are profoundly important natural
products, forming the foundations of many therapeutic regimes. Decades of research have …

Bacterial natural products are a diverse and valuable group of small molecules, and genome
sequencing indicates that the vast majority remain undiscovered. The prediction of natural …

Single-cell transcriptomics provides an opportunity to characterize cell-type-specific transcriptional
networks, intercellular signaling pathways and cellular diversity with unprecedented …

Deep generative models are powerful tools for the exploration of chemical space, enabling
the on-demand generation of molecules with desired physical, chemical or biological …