User profiles for Michael Boyle

Michael Boyle

Johns Hopkins University School of Medicine
Verified email at jhmi.edu
Cited by 15055

Ontario Child Health Study: reliability and validity of the general functioning subscale of the McMaster Family Assessment Device

J Byles, C Byrne, MH Boyle, DR Offord - Family process, 1988 - Wiley Online Library
The reliability and validity of the 12‐item General Functioning (GF) subscale of the McMaster
Family Assessment Device (FAD) is reported here. Psychometric properties of the FAD …

Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation

…, RS Amin, MA Ashlock, M Ballmann, MP Boyle… - Thorax, 2012 - thorax.bmj.com
Background VX-809, a cystic fibrosis transmembrane conductance regulator (CFTR) modulator,
has been shown to increase the cell surface density of functional F508del-CFTR in vitro. …

Chronic illness, disability, and mental and social well-being: findings of the Ontario Child Health Study

D Cadman, M Boyle, P Szatmari, DR Offord - Pediatrics, 1987 - publications.aap.org
Chronic childhood illness, disability, and psychosocial problems are receiving major attention
in current pediatric care. Much of the evidence associating chronic physical problems and …

The influence of organic matter on soil aggregation and water infiltration

M Boyle, WT Frankenberger Jr… - Journal of production …, 1989 - Wiley Online Library
The unimpeded flow of water down through the soil is essential to agricultural production.
Intensive cultivation can disrupt soil structure and restrict infiltration, which results in inefficient …

[HTML][HTML] Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR

…, F Ratjen, SM Rowe, D Waltz, MP Boyle - … England Journal of …, 2015 - Mass Medical Soc
Background Cystic fibrosis is a life-limiting disease that is caused by defective or deficient
cystic fibrosis transmembrane conductance regulator (CFTR) protein activity. Phe508del is the …

Soluble human complement receptor type 1: in vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis

…, HC Marsh Jr, GR Carson, MF Concino, MP Boyle… - Science, 1990 - science.org
The complement system is an important mediator of the acute inflammatory response, and
an effective inhibitor would suppress tissue damage in many autoimmune and inflammatory …

Ontario Child Health Study: II. Six-month prevalence of disorder and rates of service utilization

DR Offord, MH Boyle, P Szatmari… - Archives of general …, 1987 - jamanetwork.com
• We studied the six-month prevalence of four child psychiatric disorders (conduct disorder,
hyperactivity, emotional disorder, and somatization) and patterns of service utilization for …

Childhood abuse and lifetime psychopathology in a community sample

…, DL Streiner, E Lin, MH Boyle… - American Journal of …, 2001 - Am Psychiatric Assoc
OBJECTIVE: The authors assessed lifetime psychopathology in a general population sample
and compared the rates of five psychiatric disorder categories between those who reported …

Inflammatory subtypes in asthma: assessment and identification using induced sputum

JL Simpson, R Scott, MJ Boyle, PG Gibson - Respirology, 2006 - Wiley Online Library
Objective: The authors sought to investigate the detection of non‐eosinophilic asthma using
induced sputum. Although this is an important subtype of clinical asthma, its recognition is …

[HTML][HTML] Effect of VX-770 in Persons with Cystic Fibrosis and the G551D-CFTR Mutation

…, SM Rowe, JP Clancy, MP Boyle… - … England Journal of …, 2010 - Mass Medical Soc
Background A new approach in the treatment of cystic fibrosis involves improving the function
of mutant cystic fibrosis transmembrane conductance regulator (CFTR). VX-770, a CFTR …