Objective Opioid use disorder has been declared a public health crisis across North America
and opioid agonist therapy (OAT) is the standard of care for these patients. Despite the …

Background Whether used for pain management or recreation, opioids have a number of
adverse effects including hormonal imbalances. These imbalances have been reported to …

Background Despite the growing numbers of men and women with opioid use disorder in
Canada, sex-specific issues in treatment have not been re-examined in the current population …

Background Opioids are psychoactive analgesic drugs prescribed for pain relief and palliative
care. Due to their addictive potential, effort and vigilance in controlling prescriptions is …

Introduction Concomitant opioid abuse is a serious problem among patients receiving methadone
maintenance treatment (MMT) for opioid use disorder. This is an exploratory study that …

Background: Opioid use disorder is a serious international concern with limited treatment
success. Men and women differ in their susceptibility to opioid use disorder and response to …

Background Opioid use disorder (OUD) affects approximately 21.9 million people worldwide.
This study aims to determine the association between age of onset of opioid use and …

Virtually all psychiatric and substance use disorders are associated with sleep disruption.
Studies indicate that psychiatric disorders are related closely to chronic insomnia and that …

Sex hormones may have a role in the pathophysiology of substance use disorders, as
demonstrated by the association between testosterone and addictive behaviour in opioid …

Background While a number of pharmacological interventions exist for the treatment of opioid
use disorder, evidence evaluating the effect of pain on substance use behavior, attrition …