Background Patients with neutropenia and persistent fever are often treated empirically with
amphotericin B or liposomal amphotericin B to prevent invasive fungal infections. Antifungal …

Objectives: To determine whether emergency colectomy reduces mortality in patients with
fulminant Clostridium difficile-associated disease (CDAD), and to identify subgroups of …

BACKGROUND The overall clinical efficacy of the azoles antifungal agents and low‐dose
intravenous amphotericin B for antifungal chemoprophylaxis in patients with malignant …

Objectives: To illustrate the progressive loss of cross-echinocandin activity on Candida
albicans isolates with strong clonal homology from a patient with advanced HIV infection and …

Since 2002, an epidemic of Clostridium difficile infections has occurred in southern Quebec,
Canada. At Hôpital Maisonneuve-Rosemont, Montreal, Quebec, Canada, the incidence of …

Background. Reported sensitivity of the galactomannan enzyme immunoassay as an early
diagnostic test for invasive aspergillosis (IA) has been widely variable, ranging from 29% to …

Azoles are the mainstay of oral therapy for aspergillosis. Azole resistance in Aspergillus has
been reported infrequently. The first resistant isolate was detected in 1999 in Manchester, …

We report a randomized, double-blind, multicenter trial in which amphotericin B colloidal
dispersion (ABCD [Amphotec]; 6 mg/kg/day) was compared with amphotericin B (AmB; 1.0–1.5 …

A randomized, double-blind trial comparing oral fluconazole (400 mg daily) with placebo as
prophylaxis for adult patients receiving intensive cytotoxic therapy for acute leukemia or …

Seventeen laboratories participated in a study of interlaboratory reproducibility with caspofungin
microdilution susceptibility testing against panels comprising 30 isolates of Candida spp…