[HTML][HTML] Role of dietary fatty acids in mammary gland development and breast cancer

M MacLennan, DWL Ma - Breast Cancer Research, 2010 - Springer
Breast cancer is the most common cancer among women worldwide. Estimates suggest up
to 35% of cases may be preventable through diet and lifestyle modification. Growing …

Mammary tumor development is directly inhibited by lifelong n-3 polyunsaturated fatty acids

MB MacLennan, SE Clarke, K Perez, GA Wood… - The Journal of nutritional …, 2013 - Elsevier
INTRODUCTION: Despite the advocacy that diet may be a significant contributor to cancer
prevention, there is a lack of direct evidence from epidemiological and experimental studies to …

Management of severe frostbite with iloprost, alteplase and heparin: a Yukon case series

A Poole, J Gauthier, M MacLennan - Canadian Medical Association …, 2021 - cmajopen.ca
Background: We identified the need to modernize frostbite management in our northern
centre and implemented a treatment protocol in 2015. Our aim was to describe the clinical …

Lifelong exposure to n-3 PUFA affects pubertal mammary gland development

BM Anderson, MB MacLennan… - Applied Physiology …, 2014 - cdnsciencepub.com
There is growing evidence that early developmental periods may importantly influence future
breast cancer risk. Also, there is great interest in the role of dietary fat in breast cancer risk, …

[HTML][HTML] Differential mammary gland development in FVB and C57Bl/6 mice: implications for breast cancer research

MB MacLennan, BM Anderson, DWL Ma - Nutrients, 2011 - mdpi.com
A growing body of research suggests a linkage between pubertal mammary gland development
and environmental factors such as diet as modifiers of long term breast cancer risk. …

[HTML][HTML] Menhaden oil, but not safflower or soybean oil, aids in restoring the polyunsaturated fatty acid profile in the novel delta-6-desaturase null mouse

J Monteiro, FJ Li, M MacLennan, A Rabalski… - Lipids in health and …, 2012 - Springer
Background Polyunsaturated fatty acids (PUFA) have diverse biological effects, from promoting
inflammation to preventing cancer and heart disease. Growing evidence suggests that …

Use of fluorescence to visualize response to iloprost treatment for frostbite

M MacLennan, A Poole, J Gauthier - CMAJ, 2021 - Can Med Assoc
Figure 1: Microvascular assessment of frostbite in the left foot of a 48-year-old man using
intravenous indocyanine green.(A) 12 hours after frostbite, before iloprost treatment, with flow …

Mammary tumour development in fat-1 x MMTV-neu (ndl)-YD5 mice is inhibited by n-3 PUFA

MB MacLennan - 2011 - atrium.lib.uoguelph.ca
Experimental studies suggest that n-3 polyunsaturated fatty acids (n-3 PUFA) may have the
potential to modulate mammary gland development and reduce breast cancer (BC) risk. …

Differential Mammary Gland Development in FVB and C57Bl/6 Mice: Implications for Breast Cancer Research

BM Anderson, DWL Ma, MB MacLennan - 2011 - agris.fao.org
A growing body of research suggests a linkage between pubertal mammary gland development
and environmental factors such as diet as modifiers of long term breast cancer risk. …

[HTML][HTML] Genomic and phenotypic characterization of 404 individuals with neurodevelopmental disorders caused by CTNNB1 variants

…, M Bertoli, N Foulds, S McKee, AH MacLennan… - Genetics in …, 2022 - Elsevier
Purpose Germline loss-of-function variants in CTNNB1 cause neurodevelopmental disorder
with spastic diplegia and visual defects (NEDSDV; OMIM 615075) and are the most frequent…