User profiles for Naglaa H. Shoukry
 | Naglaa H. ShoukryProfessor of Medicine, Université de Montréal and Centre de Recherche du CHUM … Verified email at umontreal.ca Cited by 7334 |
HCV persistence and immune evasion in the absence of memory T cell help
A Grakoui, NH Shoukry, DJ Woollard, JH Han… - Science, 2003 - science.org
Spontaneous resolution of hepatitis C virus (HCV) infection in humans usually affords long-term
immunity to persistent viremia and associated liver diseases. Here, we report that …
immunity to persistent viremia and associated liver diseases. Here, we report that …
Memory CD8+ T Cells Are Required for Protection from Persistent Hepatitis C Virus Infection
NH Shoukry, A Grakoui, M Houghton… - The Journal of …, 2003 - rupress.org
Few hepatitis C virus (HCV) infections resolve spontaneously but those that do appear to
afford protective immunity. Second infections are usually shorter in duration and are less likely …
afford protective immunity. Second infections are usually shorter in duration and are less likely …
Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection
…, MR Boulassel, J Bruneau, NH Shoukry… - Nature medicine, 2010 - nature.com
Viral replication and microbial translocation from the gut to the blood during HIV infection
lead to hyperimmune activation, which contributes to the decline in CD4 + T cell numbers …
lead to hyperimmune activation, which contributes to the decline in CD4 + T cell numbers …
[PDF][PDF] The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection
…, BH McGovern, J Schinkel, J George, NH Shoukry… - …, 2014 - Wiley Online Library
Although 20%‐40% of persons with acute hepatitis C virus (HCV) infection demonstrate
spontaneous clearance, the time course and factors associated with clearance remain poorly …
spontaneous clearance, the time course and factors associated with clearance remain poorly …
[PDF][PDF] Interleukin-10 directly inhibits CD8+ T cell function by enhancing N-glycan branching to decrease antigen sensitivity
Chronic viral infections remain a global health concern. The early events that facilitate viral
persistence have been linked to the activity of the immunoregulatory cytokine IL-10. However, …
persistence have been linked to the activity of the immunoregulatory cytokine IL-10. However, …
Limited T cell receptor diversity of HCV-specific T cell responses is associated with CTL escape
…, NH Shoukry, KW Brady, H Kim… - The Journal of …, 2004 - rupress.org
Escape mutations are believed to be important contributors to immune evasion by rapidly
evolving viruses such as hepatitis C virus (HCV). We show that the majority of HCV-specific …
evolving viruses such as hepatitis C virus (HCV). We show that the majority of HCV-specific …
Cell-mediated immunity and the outcome of hepatitis C virus infection
NH Shoukry, AG Cawthon, CM Walker - Annu. Rev. Microbiol., 2004 - annualreviews.org
▪ Abstract The hepatitis C virus (HCV) infects approximately three percent of the world's
population. Some individuals resolve the infection spontaneously, but the majority develop …
population. Some individuals resolve the infection spontaneously, but the majority develop …
[HTML][HTML] Galectin-9 and IL-21 mediate cross-regulation between Th17 and Treg cells during acute hepatitis C
…, T Fabre, N Bedard, J Bruneau, NH Shoukry - PLoS …, 2013 - journals.plos.org
Loss of CD4 T cell help correlates with virus persistence during acute hepatitis C virus (HCV)
infection, but the underlying mechanism(s) remain unknown. We developed a combined …
infection, but the underlying mechanism(s) remain unknown. We developed a combined …
Early Interferon Therapy for Hepatitis C Virus Infection Rescues Polyfunctional, Long-Lived CD8+ Memory T Cells
…, RP Sékaly, J Bruneau, NH Shoukry - Journal of …, 2008 - Am Soc Microbiol
The majority of acute hepatitis C virus (HCV) infections progress to chronicity and progressive
liver damage. Alpha interferon (IFN-α) antiviral therapy achieves the highest rate of …
liver damage. Alpha interferon (IFN-α) antiviral therapy achieves the highest rate of …
Hepatitis C Virus Reinfection and Spontaneous Clearance of Reinfection—the InC3 Study
…, InC3 study group, NH Shoukry… - The Journal of …, 2015 - academic.oup.com
… Kim, on behalf of the InC3 study group, Barbara H. McGovern, on behalf of the InC3 study
group, Naglaa H. Shoukry, on behalf of the InC3 study group, Janke Schinkel, on behalf of the …
group, Naglaa H. Shoukry, on behalf of the InC3 study group, Janke Schinkel, on behalf of the …
