User profiles for Nicholas Mitsakakis

Nicholas Mitsakakis

Children's Hospital of Eastern Ontario Research Institute
Verified email at theta.utoronto.ca
Cited by 5136

[HTML][HTML] Exploration of essential gene functions via titratable promoter alleles

…, SL Hiley, Z Li, Q Morris, J Grigull, N Mitsakakis… - Cell, 2004 - cell.com
Nearly 20% of yeast genes are required for viability, hindering genetic analysis with knockouts.
We created promoter-shutoff strains for over two-thirds of all essential yeast genes and …

Ultrasound assessment of gastric content and volume

…, VWS Chan, CM Lupu, N Mitsakakis… - The Journal of the …, 2009 - pubs.asahq.org
Background Aspiration of gastric contents can be a serious perioperative complication,
attributing up to 9% of all anesthesia-related deaths. However, there is currently no practical, …

Validation of a mathematical model for ultrasound assessment of gastric volume by gastroscopic examination

A Perlas, N Mitsakakis, L Liu, M Cino… - Anesthesia & …, 2013 - journals.lww.com
METHODS: Patients undergoing elective UGE were randomized to ingest one of 6
predetermined volumes of apple juice after an 8-hour fasting period. A cross-sectional area of the …

Gastric sonography in the fasted surgical patient: a prospective descriptive study

A Perlas, L Davis, M Khan, N Mitsakakis… - Anesthesia & …, 2011 - journals.lww.com
BACKGROUND: Aspiration pneumonia remains a serious anesthetic-related complication.
A reliable diagnostic tool to assess gastric volume is currently lacking. We recently …

[HTML][HTML] The functional landscape of mouse gene expression

…, R Chang, O Shai, MA Bakowski, N Mitsakakis… - Journal of biology, 2004 - Springer
Background Large-scale quantitative analysis of transcriptional co-expression has been
used to dissect regulatory networks and to predict the functions of new genes discovered by …

[HTML][HTML] A panoramic view of yeast noncoding RNA processing

…, J Grigull, X Yang, W Zhang, N Mitsakakis… - Cell, 2003 - cell.com
Predictive analysis using publicly available yeast functional genomics and proteomics data
suggests that many more proteins may be involved in biogenesis of ribonucleoproteins than …

Preoperative use of statins is associated with reduced early delirium rates after cardiac surgery

…, L Fedorko, J Karski, N Mitsakakis… - The Journal of the …, 2009 - pubs.asahq.org
Background Delirium is an acute deterioration of brain function characterized by fluctuating
consciousness and an inability to maintain attention. Use of statins has been shown to …

Adding gabapentin to a multimodal regimen does not reduce acute pain, opioid consumption or chronic pain after total hip arthroplasty

…, D Kennedy, J Andrion, N Mitsakakis… - Acta …, 2009 - Wiley Online Library
Background: Gabapentin (GPN) is effective in reducing post‐operative pain and opioid
consumption, but its effects with regional anesthesia for total hip arthroplasty (THA) are not known…

The effect of cardiac rehabilitation on health-related quality of life in patients with coronary artery disease: a meta-analysis

T Francis, N Kabboul, V Rac, N Mitsakakis… - Canadian Journal of …, 2019 - Elsevier
Background The clinical effectiveness of cardiac rehabilitation (CR) on health-related quality
of life (HRQOL) is an area that has not been consistently explored. The objective of this …

Acute surgical anemia influences the cardioprotective effects of β-blockade: a single-center, propensity-matched cohort study

…, S McCluskey, G Tait, N Mitsakakis… - The Journal of the …, 2010 - pubs.asahq.org
Background Despite decreasing cardiac events, perioperative beta-blockade also increases
perioperative stroke and mortality. Major bleeding and/or hypotension are independently …