User profiles for Patrick E. Steadman

Patrick Steadman

Faculty of Medicine, University of Toronto
Verified email at mail.utoronto.ca
Cited by 1589

[PDF][PDF] Disruption of oligodendrogenesis impairs memory consolidation in adult mice

PE Steadman, F Xia, M Ahmed, AJ Mocle… - Neuron, 2020 - cell.com
Steadman et al. find that blocking this form of adaptive myelination prevents learning-induced …
(D and E) Mrf deletion decreased the density of tagged oligodendrocyte lineage cells (D) …

[PDF][PDF] Chemogenetic interrogation of a brain-wide fear memory network in mice

G Vetere, JW Kenney, LM Tran, F Xia, PE Steadman… - Neuron, 2017 - cell.com
Behavior depends on coordinated activity across multiple brain regions. Within such networks,
highly connected hub regions are assumed to disproportionately influence behavioral …

Genetic effects on cerebellar structure across mouse models of autism using a magnetic resonance imaging atlas

PE Steadman, J Ellegood, KU Szulc… - Autism …, 2014 - Wiley Online Library
Magnetic resonance imaging ( MRI ) of autism populations is confounded by the inherent
heterogeneity in the individuals' genetics and environment, two factors difficult to control for. …

[PDF][PDF] Mesenchymal precursor cells in adult nerves contribute to mammalian tissue repair and regeneration

MJ Carr, JS Toma, APW Johnston, PE Steadman… - Cell stem cell, 2019 - cell.com
Peripheral innervation plays an important role in regulating tissue repair and regeneration.
Here we provide evidence that injured peripheral nerves provide a reservoir of mesenchymal …

Memory formation in the absence of experience

G Vetere, LM Tran, S Moberg, PE Steadman… - Nature …, 2019 - nature.com
Memory is coded by patterns of neural activity in distinct circuits. Therefore, it should be
possible to reverse engineer a memory by artificially creating these patterns of activity in the …

A 3D adult zebrafish brain atlas (AZBA) for the digital age

JW Kenney, PE Steadman, O Young, MT Shi… - Elife, 2021 - elifesciences.org
Zebrafish have made significant contributions to our understanding of the vertebrate brain
and the neural basis of behavior, earning a place as one of the most widely used model …

MRI-detectable changes in mouse brain structure induced by voluntary exercise

LS Cahill, PE Steadman, CE Jones, CL Laliberté… - NeuroImage, 2015 - Elsevier
Physical exercise, besides improving cognitive and mental health, is known to cause structural
changes in the brain. Understanding the structural changes that occur with exercise as …

Sex differences in neurology: a scoping review

…, PE Steadman, A Momen, E Wolff, A Pikula, E Bui - BMJ open, 2023 - bmjopen.bmj.com
Objective Historically, neurology research has demonstrated a sex bias with mainly male
subjects included in clinical trials as well as lack of reporting of data by sex. In recent years, …

Characteristics and outcomes of Canadian MD/PhD program graduates: a cross-sectional survey

…, JX Ji, A Kuzyk, X Wang, PE Steadman… - … Open Access Journal, 2017 - cmajopen.ca
Background: Combined MD/PhD programs provide a structured path for physician-scientist
training, but assessment of their success within Canada is limited by a lack of quantitative …

Training the next generation of Canadian Clinician-Scientists: charting a path to success

C Yin, PE Steadman, T Apramian… - Clinical and …, 2017 - utpjournals.press
Clinician-scientists are physicians with training in both clinical medicine and research that
enables them to occupy a unique niche as specialists in basic and translational biomedical …