Red cell (RBC) transfusions are a potentially life‐saving therapy employed during the care
of many critically ill patients to replace losses in hemoglobin to maintain oxygen delivery to …

Background Vasopressin is commonly used as an adjunct to catecholamines to support blood
pressure in refractory septic shock, but its effect on mortality is unknown. We hypothesized …

Background To determine whether a restrictive strategy of red-cell transfusion and a liberal
strategy produced equivalent results in critically ill patients, we compared the rates of death …

Background The optimal hemoglobin threshold for erythrocyte transfusions in critically ill
children is unknown. We hypothesized that a restrictive transfusion strategy of using packed red …

Background Antifibrinolytic agents are commonly used during cardiac surgery to minimize
bleeding and to reduce exposure to blood products. We sought to determine whether …

Background There is considerable uncertainty regarding the optimal haemoglobin threshold
for the use of red blood cell (RBC) transfusions in anaemic patients. Blood is a scarce …

… Hébert and Wells and Mr. Schweitzer and Ms. Yetisir); and the Departments of Pathology
and Medicine, McMaster University (Dr. … Hebert PC, Wells G, Tweeddale M, et al: Does …

Background Hypothermia therapy improves survival and the neurologic outcome in animal
models of traumatic brain injury. However, the effect of hypothermia therapy on the …

Background Fresh red cells may improve outcomes in critically ill patients by enhancing
oxygen delivery while minimizing the risks of toxic effects from cellular changes and the …

Comment 1910 www. thelancet. com Vol 369 June 9, 2007 require registration, and the
registration of trial results. As is always the case, the ICMJE establishes policy only for the 12 …