Atherosclerotic disease remains the leading cause of death in industrialized nations despite
major advances in its diagnosis, treatment, and prevention. The increasing epidemic of …

Background: Most proton pump inhibitors inhibit the bioactivation of clopidogrel to its active
metabolite. The clinical significance of this drug interaction is unknown. Methods: We …

and by CD40/CD40 ligand (CD40L and CD154) interactions. 18–22 Once adherent, the
monocytes transmigrate into the tunica intima, the innermost layer of the arterial wall, passing …

Background— Myocardial ischemia provides a potent stimulus to angiogenesis, and the
mobilization and differentiation of endothelial progenitor cells (EPCs) has been shown to be …

The mobilization and incorporation of BM-derived EPCs has recently been shown to
modulate reendothelialization at sites of endothelial cell damage. 18, 19 Both studies induced …

and modulation of matrix metalloproteinase (MMP) activity, toward conditions favoring
compromise of the fibrous cap. 27–29 On plaque rupture, activated platelets may interact with the …

Background— Because complement-mediated vascular injury participates in atherosclerosis
and C-reactive protein (CRP) can activate the complement cascade, we sought to …

Cardiovascular disease remains a leading cause of death throughout the world despite
advances in its detection and treatment. Commonly used risk algorithms, such as the …

Altered macrophage kinetics is a pivotal mechanism of visceral obesity-induced inflammation
and cardiometabolic risk. Because monocytes can differentiate into either proatherogenic …

The cardiometabolic syndrome, associated with increased cardiovascular disease risk in
the industrialized world, is estimated to affect one in four adults. Although the mechanisms …