Aims There is concern about the infection-related safety profile of sodium–glucose co-transporter
2 (SGLT-2) inhibitors. We aimed to determine the effect of SGLT-2 inhibitors on …

Background and Purpose— There is no consensus on the comparative efficacy and safety
of carotid artery stenting (CAS) versus carotid endarterectomy (CEA) in patients with …

Background— Although the efficacy and safety of smoking cessation interventions are well
established, their efficacy and safety in patients with cardiovascular disease (CVD) remain …

Background: Cholesteryl ester transfer protein (CETP) inhibitors increase serum high-density
lipoprotein cholesterol (HDL-c) concentration; however, their impact on cardiovascular …

Background: With the recent legalization of recreational cannabis in Canada, cannabis-impaired
driving is an important public safety concern. Our aim was to examine the association …

Background Hypertensive disorders in pregnancy ( HDP ) have been shown to predict later
risk of cardiovascular disease ( CVD ). However, previous studies have not accounted for …

Importance Ondansetron is frequently used to treat nausea and vomiting during pregnancy.
Although some studies reported important safety signals, few studies have been sufficiently …

Introduction Postoperative ileus (POI) is regarded as the most clinically significant morbidity
following loop ileostomy closure; however, its incidence remains poorly understood. Our …

Background There are no head-to-head randomized controlled trials comparing different
direct oral anticoagulants (DOACs). Thus, we systematically reviewed and meta-analyzed …

Background Time‐related biases, such as immortal time and time‐window bias, frequently
occur in pharmacoepidemiologic research. However, the prevalence of these biases in …