Importance Little is known about the relationship between perioperative high-sensitivity
troponin T (hsTnT) measurements and 30-day mortality and myocardial injury after noncardiac …

Background Perioperative bleeding is common in patients undergoing noncardiac surgery.
Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding. Methods …

RESEARCH Page 1 Features of effective computerised clinical decision support systems:
meta-regression of 162 randomised trials OPEN ACCESS Pavel S Roshanov medical student1…

Background The effect on cardiovascular outcomes of withholding angiotensin-converting
enzyme inhibitors or angiotensin II receptor blockers in chronic users before noncardiac …

Background The use of computerized clinical decision support systems (CCDSSs) may
improve chronic disease management, which requires recurrent visits to multiple health …

Background Underuse and overuse of diagnostic tests have important implications for health
outcomes and costs. Decision support technology purports to optimize the use of diagnostic …

Importance Acute kidney injury, a common complication of surgery, is associated with poor
outcomes and high health care costs. Some studies suggest aspirin or clonidine …

Objective The US Agency for Healthcare Research and Quality funded an evidence report
to address seven questions on multiple aspects of the effectiveness of medication …

Background Clinical guidelines caution against nonsteroidal anti-inflammatory drug (NSAID)
use in older adults. The study objective was to quantify the 30-day risk of acute kidney …

Objective To determine if virtual care with remote automated monitoring (RAM) technology
versus standard care increases days alive at home among adults discharged after non-…