IL-1β is one of a family of proinflammatory cytokines thought to be involved in many acute
and chronic diseases. Although it is considered to participate in wound repair, no major role …

Rationale: The clinical management of idiopathic pulmonary fibrosis (IPF) remains a major
challenge due to lack of effective drug therapy or accurate indicators for disease progression. …

Transforming growth factor-β1 plays a key role in the pathogenesis of pulmonary fibrosis,
mediating extracellular matrix (ECM) gene expression through a series of intracellular …

Epithelial mesenchymal transition (EMT), a process involved in many growth and repair
functions, has been identified in the peritoneal tissues of patients who undergo peritoneal …

Transforming growth factor (TGF)-β is a key cytokine in the pathogenesis of pulmonary fibrosis,
and pharmacological interference with TGF-β can ameliorate the fibrotic tissue response. …

The development of peritoneal dialysis (PD) as a successful therapy has and still depends
on experimental models to test and understand critical pieces of pathophysiology. To date, …

Transient adenovirus-mediated gene transfer of IL-1β (AdIL-1β), a proinflammatory cytokine,
induces marked inflammation and severe and progressive fibrosis in rat lungs. This is …

Peritoneal membrane solute transport in peritoneal dialysis (PD) patients is assessed by the
peritoneal equilibration test, which measures the ratio of creatinine in the dialysate to …

Pulmonary fibrosis is characterized by chronic scar formation and deposition of extracellular
matrix, resulting in impaired lung function and respiratory failure. Idiopathic pulmonary …

Abstract. Long-term peritoneal dialysis is limited by physiologic changes in the peritoneum
that lead to ultrafiltration failure. To determine the role of profibrotic cytokines in the alteration …