Type I spiral ganglion neurons (SGNs) are the auditory afferents that transmit sound
information from cochlear inner hair cells (IHCs) to the brainstem. These afferents consist of …

Environmental sustainability has emerged as a key issue amongst governments, policymakers,
researchers, companies and the general public. In Europe, governments are trying to …

Background Up to 1/2 of outpatients prescribed clozapine may be partially/fully non-adherent,
based on therapeutic drug monitoring (TDM). Three indices for measuring partial/full non-…

The hair cell ribbon synapses of the mammalian auditory and vestibular systems differ greatly
in their anatomical organization and firing properties. Notably, vestibular Type I hair cells (…

Background Major depressive disorder (MDD) is the leading cause of disability worldwide.
Of individuals with MDD, 30% to 50% are unresponsive to common antidepressants, …

Objective: Medication adherence is extremely important in preventing relapse and lowering
symptoms in schizophrenic patients. However, estimates show that nearly half of these …

A membrane-type vacuum consolidation system, including surcharge loading and
prefabricated vertical drains, was applied to rapidly consolidate soft clay beneath a circular …

The Signature Biobank is a longitudinal repository of biospecimen, psychological,
sociodemographic, and diagnostic data that was created in 2012. The Signature Consortium …

Background: Bupropion is a dopamine and norepinephrine reuptake inhibitor approved for
the treatment of depression and smoking cessation. According to the recently published …

The mechanisms orchestrating transient and sustained exocytosis in auditory inner hair
cells (IHCs) remain largely unknown. These exocytotic responses are believed to mobilize …