The transition between soluble intrinsically disordered tau protein and aggregated tau in
neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau …

Simulation studies using susceptible-infectious-recovered models were conducted to
estimate individuals' risk of infection and time to infection in small-world and randomly mixing …

Repetitive mild or “concussive” traumatic brain injury (TBI) can cause substantial neurologic
impairment, but the pathological features of this type of injury are not fully understood. We …

Objective To investigate the prevalence and significance of increased left ventricular (LV)
trabeculation in highly trained athletes. Design Cross sectional echocardiographic study. …

Tau is the major constituent of neurofibrillary tangles in Alzheimer's disease (AD), but the
mechanism underlying tau-associated neural damage remains unclear. Here, we show that tau …

Mixed pathology, with both Alzheimer’s disease and vascular abnormalities, is the most
common cause of clinical dementia in the elderly. While usually thought to be concurrent …

Migration through micron-size constrictions has been seen to rupture the nucleus, release
nuclear-localized GFP, and cause localized accumulations of ectopic 53BP1—a DNA repair …

Amyloid plaques and neurofibrillary tangles co-occur in Alzheimer disease, but with
different topological and temporal patterns. Whether these two lesions are independent or …

We show that Vibrio cholerae, the causative agent of cholera, use their flagella and
mannose-sensitive hemagglutinin (MSHA) type IV pili synergistically to switch between two …

A private practice was surveyed for prevalence of inflammatory bowel disease (IBD) in
husband-wife partners and in their children. Among approximately 2500 patients with IBD in our …