Background: The annual cut-off date of birth for entry to school in British Columbia, Canada,
is Dec. 31. Thus, children born in December are typically the youngest in their grade. We …

Limited evidence suggests that isotretinoin may be associated with inflammatory bowel
disease (IBD). To explore this association, we conducted a retrospective population-based …

Background The use of diuretics, statins, and inhaled long-acting β2-agonists (LABAs) is
linked to muscle cramps but largely by anecdotal evidence. This study sought population-level …

Background: It has been anecdotally reported that nocturnal leg cramps in pregnant women
are worse in summer. We analyzed population-level data to determine whether the symptom …

… Mr Morrow accepts full responsibility for the work and the conduct of the study, had access …
study, Mr Morrow; substantial contributions to design of the work, Mr Morrow and Drs Mintzes, …

Objectives Tramadol is a widely prescribed analgesic that influences both opioid and monoamine
neurotransmission. While seizures have been reported with its use, the risk in clinical …

Background The US Food and Drug Administration (FDA) and other major regulators regularly
issue safety advisories about licensed drugs with new adverse effects that have been …

Objective To understand how the experiences and views of trial participants, trial investigators
and others connected to clinical trial research relate to whether researchers have a duty to …

Objectives To study the association between accidental opioid overdose and neurological,
respiratory, cardiac and other serious adverse events and whether risk of these adverse …

Aims This study aims to understand factors contributing to nonpublication and publication
bias in clinical trials in Canada. Methods Qualitative interviews were conducted between …