Background There is currently no objective practical guide to intensity of drug treatment for
individuals with heart failure. We hypothesised that pharmacotherapy guided by plasma …

Background— A recent landmark report has demonstrated that plasma B-type natriuretic
peptide (BNP) measured in acute coronary syndromes independently predicts mortality, heart …

Pericarditis is a common disorder that has multiple causes and presents in various primary-care
and secondary-care settings. New diagnostic techniques have improved the sampling …

Background Ferric carboxymaltose therapy reduces symptoms and improves quality of life
in patients who have heart failure with a reduced ejection fraction and iron deficiency. …

Objectives : The purpose of this study was to determine whether a new accelerated diagnostic
protocol (ADP) for possible cardiac chest pain could identify low-risk patients suitable for …

Recent guidelines have been published providing detailed guidance on specific echocardiographic
diagnostic criteria for measurements of diastolic function, chamber dimensions, right …

Objectives : The purpose of this study was to compare the effects of N-terminal pro–B-type
natriuretic peptide (NT-proBNP)-guided therapy with those of intensive clinical management …

Objectives : The study objective was to validate a new high-sensitivity troponin I (hs-TnI)
assay in a clinical protocol for assessing patients who present to the emergency department …

Background Trimethylamine-N-oxide (TMAO) has been linked to increased cardiovascular
risk. We aimed to determine the prognostic value of TMAO and its dietary precursors, choline …

Background— Previous studies suggest that management of ambulatory hemodynamics may
improve outcomes in chronic heart failure. We conducted a prospective, observational, first-…