Results are presented from a new version of the Hadley Centre coupled model (HadCM3)
that does not require flux adjustments to prevent large climate drifts in the simulation. The …

This chapter assesses the capacity of the global climate models used elsewhere in this
report for projecting future climate change. Confidence in model estimates of future climate …

An essential resource for all scientists researching cellular responses to DNA damage.•
Introduces important new material reflective of the major changes and developments that have …

This book provides a look at the theory behind the programs engineers use for the computer
simulation of nonlinear structural behaviour. It establishes the mathematical foundations for …

Faithful maintenance of the genome is crucial to the individual and to species. DNA damage
arises from both endogenous sources such as water and oxygen and exogenous sources …

Cellular DNA is subjected to continual attack, both by reactive species inside cells and by
environmental agents. Toxic and mutagenic consequences are minimized by distinct pathways …

The inability of current recommendations to control the epidemic of diabetes, the specific
failure of the prevailing low-fat diets to improve obesity, cardiovascular risk, or general health …

Eukaryotic cells have multiple mechanisms for repairing damaged DNA. 0 6 -methylguanine-DNA
methyltransferase directly reverses some simple alkylation adducts. However, most …

Part of the uncertainty in predictions by climate models results fromlimited knowledge of the
stability of the thermohaline circulation ofthe ocean. Here we provide estimates of the …

Nucleotide excision repair is the principal way by which human cells remove UV damage
from DNA. Human cell extracts were fractionated to locate active components, including …