Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance
to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of …

Background The lack of a reliable scoring system that predicts the development of septic shock
and death precludes comparison of disease and/or treatment outcomes in animal models …

The large size of poxvirus genomes has stymied attempts to identify determinants recognized
by CD8 + T cells and greatly impeded development of mouse smallpox vaccination models…

▪ Abstract CD8 + T cells play a critical role in antiviral immunity by exerting direct antiviral
activity against infected cells. Because of their ability to recognize all types of viral proteins, they …

Staphylococcal superantigens are pyrogenic exotoxins that cause massive T cell activation
leading to toxic shock syndrome and death. Despite the strong adaptive immune response …

… This work was supported by an operating grant to SM Mansour Haeryfar. The funder had
no role in study design, data collection and analysis, decision to publish, or preparation of the …

Staphylococcal superantigens (SAgs) constitute a family of potent exotoxins secreted by
Staphylococcus aureus and other select staphylococcal species. SAgs function to cross-link …

Establishing the genetic determinants of niche adaptation by microbial pathogens to specific
hosts is important for the management and control of infectious disease. Streptococcus …

Mucosa-associated invariant T (MAIT) cells are innate-like T lymphocytes that are unusually
abundant in the human liver, a common site of colorectal carcinoma (CRC) metastasis. …

The globally prominent pathogen Streptococcus pyogenes secretes potent immunomodulatory
proteins known as superantigens (SAgs), which engage lateral surfaces of major …