Methods In developing this guideline, the steering committee followed standards for trustworthy
guidelines. 15 We included innovative approaches for key standards such as patient …

Importance Harms and benefits of opioids for chronic noncancer pain remain unclear.
Objective To systematically review randomized clinical trials (RCTs) of opioids for chronic …

Systematic reviews are difficult to keep up to date, but failure to do so leads to a decay in
review currency, accuracy, and utility. We are developing a novel approach to systematic …

Objective To determine the benefits and harms of medical cannabis and cannabinoids for
chronic pain. Design Systematic review and meta-analysis. Data sources MEDLINE, EMBASE, …

Background: Persistent pain after breast cancer surgery affects up to 60% of patients. Early
identification of those at higher risk could help inform optimal management. We conducted a …

New approaches to evidence synthesis, which use human effort and machine automation in
mutually reinforcing ways, can enhance the feasibility and sustainability of living systematic …

While it is important for the evidence supporting practice guidelines to be current, that is
often not the case. The advent of living systematic reviews has made the concept of “living …

Context Pharmacological thromboprophylaxis involves balancing a lower risk of venous
thromboembolism (VTE) against a higher risk of bleeding, a trade-off that critically depends on …

A living systematic review (LSR) should keep the review current as new research evidence
emerges. Any meta-analyses included in the review will also need updating as new material …

Background: Patients and clinicians can choose from several treatment options to address
acute pain from non–low back, musculoskeletal injuries. Purpose: To assess the comparative …