© 2011 Canadian Medical Association or its licensors CMAJ, February 22, 2011, 183 (3)
E195 backgrounds in clinical and/or nonclinical expertise: 15 were experts in critical care …

Proton pump inhibitors (PPIs) and H2 receptor antagonists (H2RAs) are very commonly
prescribed drugs and are routinely used in the chronic management of gastro-esophageal reflux …

ContextRecent reports suggest an increasing occurrence and severity of Clostridium difficile–associated
disease. We assessed whether the use of gastric acid–suppressive agents is …

Objectives: (1) To establish risk factors for the development of delirium in an intensive care
unit (ICU) and (2) to determine the effect of delirium on morbidity, mortality and length of stay. …

Background: Antibiotic disruption of the normal intestinal flora is a well-known risk factor for
Clostridium difficile-associated diarrhea. Reduced gastric acidity has been suggested as a …

Objective To describe the incidence and outcomes associated with early acute kidney injury
(AKI) in septic shock and explore the association between duration from hypotension onset …

Background: The association between the use of proton pump inhibitors and the risk of
Clostridium difficile-associated disease (CDAD) is controversial. In this study we re-examined a …

… , Sandra Dial and Abbas Kezouh acquired the data, and Abbas Kezouh, Samy Suissa and
Sandra Dial … Competing interests: Sandra Dial received an honorarium from GlaxoSmithKline …

It is unclear whether practice‐related aspects of antimicrobial therapy contribute to the high
mortality from septic shock among patients with cirrhosis. We examined the relationship …

Introduction Acute haemodynamic complications are common after cardiac surgery and
optimal perioperative use of inotropic agents, typically guided by haemodynamic variables, …