The extracellular matrix (ECM) occupies a notable proportion of the CNS and contributes to
its normal physiology. Alterations to the ECM occur after neural injury (for example, in …

Objective: Failure of remyelination is a critical impediment to recovery in multiple sclerosis (MS).
Chondroitin sulfate proteoglycans (CSPGs) have been reported to accumulate in MS …

Chemokines are essential for homeostasis and activation of the immune system. The chemokine
ligand/receptor pairing CCL20/CCR6 is interesting because these molecules display …

Chemokines (chemotactic cytokines) drive and direct leukocyte traffic. New evidence
suggests that the unusual CCR6/CCL20 chemokine receptor/ligand axis provides key homing …

The Class IA phosphoinositide 3-kinase delta (PI3Kδ) has been implicated in multiple
signaling pathways involved in leukocyte activation and hence is an attractive target in many …

Chemokines regulate lymphocyte trafficking under physiologic and pathologic conditions. In
this study, we have investigated the role of CXCR3 and CXCR4 in the activation of T …

Our previous in vitro studies led to proposals that the atypical chemokine receptor CCX-CKR
is a scavenger of CCR7 ligand homeostatic chemokines. In the present study, we …

The extracellular matrix (ECM) is a complex network of scaffolding molecules that also plays
an important role in cell signalling, migration and tissue structure. In the central nervous …

Background & Aims HDV affects 4.5–13% of chronic hepatitis B (CHB) patients globally, yet
the prevalence of HDV infection in Canada is unknown. To investigate the prevalence, …

Tenofovir alafenamide fumarate (TAF) has high plasma stability resulting in fewer renal
adverse events compared to tenofovir disoproxil fumarate (TDF) in chronic hepatitis B (CHB) …