Background: Identification of therapies to prevent severe COVID-19 remains a priority. We
sought to determine whether hydroxychloroquine treatment for outpatients with SARS-CoV-2 …

Background: Sodium restriction is a nonpharmacologic treatment suggested by practice
guidelines for the management of patients with heart failure (HF). In this study, we synthesized …

Background: Chronic pain is a common and distressing symptom reported by patients with
chronic kidney disease (CKD). Clinical practice and research in this area do not appear to be …

Background Despite a temporal increase in respiratory failure in patients hospitalized with
acute heart failure (HF), clinical trials have largely not reported the incidence or associated …

Background: Pain is common in patients with chronic kidney disease (CKD). Analgesics may
be appropriate for some CKD patients. Objectives: To determine the prevalence of overall …

The introduction of next generation sequencing (NGS) technologies has revolutionized the
practice of Medical Genetics, and despite initial reticence in its application to prenatal …

Background The association between frailty and health status in patients with heart failure
with preserved ejection fraction (HFpEF) is not well known. Objectives The authors examined …

Introduction: Heart failure (HF), and especially HF with preserved ejection fraction (HFpEF),
remains a challenging condition to define. The heterogenous nature of this population may …

Background It is recommended that primary care-based physicians refer children with
overweight and obesity to multidisciplinary paediatric obesity management, which can help to …

Background Composite endpoints for estimating treatment efficacy are routinely used in
several therapeutic areas and have become complex in the number and types of component …